The Greatest Guide To indazole ring formation
Substitution at R3 which has a halogen or alkoxy group (74f–74i) triggered a slight rise in cellular potency Together with the halide analogs (74g–h) displaying greatest the potency from the group. Even further optimization brought about the discovery of 74i–j, with 74k as probably the most Lively compound from the sequence (pIC50 = 6.seventy